Fluid resuscitation based on dynamic predictors of fluid responsiveness: closed loop algorithm versus anesthesiologists

Closed-loop Fluid Resuscitation: In- Silico Study

Title of thesis: CLOSED-LOOP FLUID RESUSCITATION: INSILICO STUDY Jonathan Cary Lucas V, Master of Science, 2015 Thesis directed by: Dr. Jin-Oh Hahn Department of Mechanical Engineering This thesis validates a control-oriented model of human circulatory dynamics associated with hemorrhage and fluid resuscitation, uses this model to design a series of closed-loop controllers for fluid resuscitati...

Evaluation of a novel closed-loop fluid-administration system based on dynamic predictors of fluid responsiveness: an in silico simulation study

INTRODUCTION Dynamic predictors of fluid responsiveness have made automated management of fluid resuscitation more practical. We present initial simulation data for a novel closed-loop fluid-management algorithm (LIR, Learning Intravenous Resuscitator). METHODS The performance of the closed-loop algorithm was tested in three phases by using a patient simulator including a pulse-pressure varia...

Fluid Responsiveness and the Six Guiding Principles of Fluid Resuscitation.

Model-Based Decision Support Algorithm to Guide Fluid Resuscitation ?

Fluid resuscitation is the first choice therapy for sepctic shock. However, fluid infusion only increases cardiac output in approximately 50 % of cases, while an excess of fluid can have harmful effects. Therefore, clinicians are looking for indices to predict the effect of fluid infusion on cardiac output, before giving fluid. In this work, a minimal mathematical model of the cardiovascular sy...

Assessing Volume Status and Fluid Responsiveness in Resuscitation

Marik PE, Baram M, Vahid B: Does the central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares. Chest 2008, 134:172-178. Central venous pressure measurements are utilized in many intensive care units (ICUs), emergency departments, and operating rooms throughout the world. It is used to assess the fluid status of patients and to aid i...